Keloid ScarTissue Can Appear Due to Excess Collagen Fibers in a Wounded Site.

Scars and the Skin Healing Process

The elimination or fading of scars, lesions, and stretch marks from the skin depends on a process called “skin remodeling”.

The skin is designed to repair wounds rapidly to avoid blood loss and infections. Scars are manufactured from a rapidly formed “collagen glue” that the body brings into an damaged area for protection and strength. In ideal skin repairing, wounded skin is rapidly closed, and then the healed area is slowly reconstructed to remove the remaining collagen scars and blend the skin area into nearby skin.

Scar collagen is removed and replaced with a mixture of skin cells and invisible collagen fibers. This remodeling may continue in a skin area for up to ten years.

In children, the remodeling rate is high and scars are usually rapidly removed from damaged skin areas. But as we become adults, this rate diminishes and small scars may stay there for years.

One way to quicken remodeling is to make a small amount of controlled skin damage with a needle, laser, acid, or other means, and then let the body repair processes rebuild the skin area.

A second procedure is to use enzymes and activators of skin renewal fibroblasts to increase the body’s normal healing processes and obtain even better final results. Fibroblasts are the cells in the basal membrane of the skin and they are the precursors of all the structural elements of healthy skin, including those that give moisture, tensile strength and elasticity to skin. Enzymes dissolve or “digest” damaged and dying cells.

Wound Repair Process

Scars are always formed to reconnect skin that has been damaged. Initially, they may be red or dark and pink after the wound has healed but will become softer and flatter naturally over time, resulting in a flat, pale scar.

For reasons that are still waiting to be fully understood, some people form raised scars that are red and thick and may be itchy or painful. Others develop scars that extend beyond the site of a wound, called keloid scars.

Keloid scars are actually thick, puckered, itchy clusters of scar tissue that grow beyond the edges of an injury or incision and rarely regress. They appear when the body keeps producing tough, fibrous protein (known as collagen) after a wound has been repaired.

Keloids can appear after any type of injury to the skin, including scratches, injections, tattoos, insect bites or surgical procedures. Keloids can appear on any part of the body, but most commonly occur on earlobes, over the breastbone and on shoulders.

Keloids are fibrotic tumors characterized by a collection of atypical fibroblasts with high deposition of extracellular matrix components, especially collagen, fibronectin, elastin, and proteoglycans. Histologically, keloids contain relatively acellular centers and thick, abundant collagen bundles that form nodules in the deep dermal portion of the lesion. Keloids present a clinical problem that must be addressed as these lesions can cause great pain, pruritus (itch) and physical disfigurement, may not improve its appearance over time, and can even affect mobility if located over a joint.

Hypertrophic scars use to be difficult to distinguish from keloid scars histologically and biochemically, but unlike keloids, hypertropic scars remain confined to the wounded site and often mature and flatten out over time. Both types produce larger amounts of collagen than normal scars, but typically the hypertrophic type exhibits less collagen synthesis after about 24 weeks. Hypertrophic scars contain about twice as much glycosaminoglycans as normal scars, and this and enhanced synthetic and enzymatic reactions result in important alterations in the matrix which affects the mechanical properties of the scars, including less extensibility that makes them feel firm.

As with hypertrophic scarring, people who have developed one keloid scar are likely to be prone to this condition in the future and should speak with their doctor or surgeon if they are going to need injections or to have any form of surgery.

Atrophic scars use to cause a thinning and diminished elasticity of the skin because the loss of normal skin architecture. An example of an atrophic scar is striae distensae, also known as stretch marks.

Click to learn more about how a natural skin care solution produced by a living creature dissolves scar tissues through enzyme digestion and activates acne scar removalremodeling and helps to treat acne pimples.

- Martha Fitzharris

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